PROLINE METABOLISM IN TUMOR GROWTH AND METASTATIC PROGRESSION

Proline Metabolism in Tumor Growth and Metastatic Progression

Cancer cells show a formidable capacity to survive under stringent conditions, to elude mechanisms of control, such as apoptosis, and to resist therapy.Cancer cells reprogram their metabolism to support uncontrolled proliferation and metastatic progression.Phenotypic and functional heterogeneity are hallmarks of cancer cells, which endow them with

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Building Multi-Dimensional Induced Pluripotent Stem Cells-Based Model Platforms to Assess Cardiotoxicity in Cancer Therapies

Cardiovascular disease (CVD) complications have contributed significantly toward poor survival of cancer patients worldwide.These complications that result in myocardial and vascular damage lead to long-term multisystemic disorders.In some patient cohorts, the progression from acute to symptomatic CVD state may be accelerated due to exacerbation of

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Methods of Delivering Mechanical Stimuli to Organ-on-a-Chip

Recent advances in ill tempered gnome integrating microengineering and tissue engineering have enabled the creation of promising microengineered physiological models, known as organ-on-a-chip (OOC), for experimental medicine and pharmaceutical research.OOCs have been used to recapitulate the physiologically critical features of specific human tissu

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AN AIRPLANE WITH UNCONVENTIONALLY PLACED PROPELLER POWER UNIT

The significance of the influence of operating miken pro series 13 propellers on the aircraft aerodynamic characteristics is well-known.Wind tunnel testing of an airplane model with operating propellers is a complex task regarding the required similarity of the full-scale and the model case.Matching sufficient similarity in axial and rotational vel

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